Chlorpheniramine Maleate 0.5% + Dexamethasone 0.1% E/E drops
Indications
Chlorpheniramine Maleate 0.5% + Dexamethasone 0.1% E/E drops is used for:
Steroid responsive bacterial allergic conditions of eye and ear, Otitis externa.
Adult Dose
Adult and Child: 2-4 drop, 3 to 4 times daily,
Child Dose
Renal Dose
Administration
Contra Indications
Known hypersensitivity. Fresh herpes simplex cornealis, tubercular processes involving the conjunctiva, the cornea and the anterior uvea. Perforated ear drum. Herpes simplex of ear, mycosis.
Precautions
Dexamethasone and Chloramphenicol Eye drops must be used under strict medical supervision. Because of the possibility of inducing corneal abscess, fungal keratopathy or glaucoma the patient should be referred to an ophthalmologist if the eye has not responded within 48 hours.
Pregnancy-Lactation
Interactions
Chlorpheniramine Maleate: Potentiates sedative effect of psychotropic drugs e.g. barbiturates, hypnotics, opioid analgesics, anxiolytics and antipsychotics. Interaction with alcohol could be dangerous (sedation/excitation).
Dexamethasone: Increased risk of hypokalaemia when used concurrently with potassium-depleting drugs such as amphotericin B and loop diuretics. Reduces efficacy of isoniazid, salicylates, vaccines and toxoids. Increased activity of dexamethasone and cyclosporin when used together. Concurrent use with aspirin or ethanol may lead to increased GI side effects.
Potentially Fatal: Reduced efficacy in combination with ephedrine, cholestyramine, phenytoin, phenobarbital and rifampicin.
Adverse Effects
Side effects of Chlorpheniramine Maleate 0.5% + Dexamethasone 0.1% E/E drops :
The local use of dexamethasone over a prolonged period may lead in some cases to secondary glaucoma and the development of complicated cataract. Ototoxicity.
Mechanism of Action
Chlorphenamine is an H1-receptor antagonist which competetively blocks H1-receptor sites on tissues.
Dexamethasone is a synthetic glucocorticoid which decreases inflammation by inhibiting the migration of leukocytes and reversal of increased capillary permeability. It suppresses normal immune response.