Chlorpheniramine + Phenylephrine + Bromhexine
Indications
Chlorpheniramine + Phenylephrine + Bromhexine is used for:
Nasal Congestion, Sneezing, Cough, Common Cold, Hay Fever, Allergic Rhinitis
Adult Dose
Nasal Congestion, Sneezing, Cough, Common Cold, Hay Fever, Allergic Rhinitis
1 tablet PO q8hr
Child Dose
Nasal Congestion, Sneezing, Cough, Common Cold, Hay Fever, Allergic Rhinitis
>12 Years Old
1 tablet PO q8hr
Renal Dose
Administration
Contra Indications
Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer
Precautions
Patient w/ history of peptic ulceration, asthma. Severe hepatic or renal impairment.
Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis when administering phenylephrine; in hypovolemia, phenylephrine use is not a substitute for replacement of blood, fluids and electrolytes, and plasma (promptly restore with loss); dilute IV and administer via large vein; extravasation precautions required
Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates
Lactation: excretion in milk unknown/contraindicated
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Chlorpheniramine + Phenylephrine + Bromhexine :
Angioedema, rash, urticaria, pruritus, bronchospasm, nausea, vomiting, dizziness, sweating, headache, diarrhoea, upper abdominal pain, transient increase in serum aminotransferase values. Hypertension, Hypotension, Palpitations, Reflex tachycardia, Severe peripheral and visceral vasoconstriction, Tachycardia, Confusion, Depression, Distress, Dizziness, Excitability, Euphoria, Fatigue, Headache, Insomnia, Irritability, Restlessness, Sedation, Tremor, Anorexia, Agranulocytosis, Hemolytic anemia, Thrombocytopenia, Thickening of bronchial secretions, Wheezing
Mechanism of Action
Bromhexine enhances mucus transport by reducing mucus viscosity and by activating the ciliated epithelium (mucociliary clearance).
Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle.
Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. It shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia.