Cilazapril
Indications
Cilazapril is used for:
Cilazapril is an ace inhibtor class drug used in the treatment of hypertension and heart failure
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Cilazapril :
Mechanism of Action
Cilazapril is a pyridazine ace inhibitor. It competes with angiotensin i for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin i to angiotensin ii. As angiotensin ii is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin ii levels results in a decrease in blood pressure, an increase in renin activity, and stimulation of baroreceptor reflex mechanisms. Kininase ii, an enzyme which degrades the vasodilator bradykinin, is identical to ace and may also be inhibited