Clevidipine
Indications
Clevidipine is used for:
Hypertension
Adult Dose
Hypertension
Infusion solution
1-2 mg/hr (2-4 mL/hr), double dose q90sec initially; as blood pressure approaches goal, increase dose by less than doubling, and increase time between adjustments to q5-10min
Maintenance: 4-6 mg/hr; not to exceed 21 mg/hr (1000 mL within 24 hour period)
Hepatic Impairment
Dose adjustment not necessary
Child Dose
Renal Dose
Renal Impairment
Dose adjustment not necessary
Administration
IV Administration
Milky white emulsion
No preservatives-use within 4 hr of puncturing stopper
Doesn't need dilution
Contra Indications
Hypersensitivity to drug, soy or egg products
Defective lipid metabolism
Acte pancreatitis if accompanied by hyperlipidemia
Severe aortic stenosis
Precautions
CHF
Risk of hypotension & reflex tachycardia
Contains no preservatives
Potential for rebound HTN after stoppage of prolonged infusion
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Not known if excreted into breast milk, do not nurse
Interactions
Adverse Effects
Side effects of Clevidipine :
>10%
AFib (21%)
Nausea (21%)
1-10%
Acute renal failure (9%)
Headache (6%)
Vomiting (3%)
<1%
Cardiac arrest
Myocardial infarction
Postmarketing Reports
Increased blood triglycerides
Ileus
Nausea
Hypersensitivity
Hypotension
Reflex tachycardia
Decreased oxygen saturation (possible pulmonary shunting)
Mechanism of Action
Calcium channel blocker (dihydropyridine): inhibits transmembrane influx of extracellular Ca ions across membranes of myocardial cells and vascular smooth muscle cells, without changing serum calcium concentrations, resulting in inhibition of cardiac and vascular smooth muscle contraction, thereby dilating main coronary and systemic arteries