Clotrimazole VT

Indications

Clotrimazole VT is used for: Vaginal itching, burning and discharge associated with recurrent vaginal yeast infections Vulvovaginal candidiasis (Vagonal thrush).

Adult Dose

Adult: Vaginal Vulvovaginal candidiasis: Clotrimazole VT 100 & 200- First infections: In general, a 3-day treatment is sufficient for Candida vaginitis. On 3 consecutive nights, Clotrimazole VT 100 or 1 Clotrimazole VT 200 are inserted as deeply as possible into the vagina. This is best achieved when lying on one’s back with the knees slightly bent. Re-infections: In general, a 6-day treatment is sufficient. This applies also to mixed infections with the above-mentioned causative organisms. On six consecutive nights, 1 Clotrimazole VT 100 is inserted as deeply as possible into the vagina. If necessary, 2 Clotrimazole VT 100 (1 in the morning and 1 in the evening) or 1 Clotrimazole VT 200 daily can be used for 6-12 days. Treatment should be timed so as to avoid the menstrual period and be finished before the onset of menstruation. To avoid re-infection, the partner should undergo local treatment with Clotrimazole Cream at the same time. Clotrimazole VT 500- Single dose, complete treatment with one vaginal tablet. The tablet should be inserted as deeply as possible in to the vagina. This is best achieved when lying on one’s back with the knees slightly bent. It is recommended that the treatment should be timed so as to avoid the menstrual period. For prevention of re-infection the partner should be treated locally with Clotrimazole Cream at the same time.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity.

Precautions

Avoid contact with eyes upon topical application. Childn <3 yrs. Pregnancy, lactation. Lactation: Excretion in milk unknown; use with caution

Pregnancy-Lactation

Pregnancy Small amounts of imidazoles may be absorbed systemically following topical and vaginal administration Lactation Excretion in milk unknown; use with caution

Interactions

Antagonism with polyene antibiotics.

Adverse Effects

Side effects of Clotrimazole VT : >10% Abnl LFTs 1-10% Mild burning, irritation, stinging to skin or vaginal area

Mechanism of Action

Clotrimazole is a broad-spectrum antifungal which binds to phospholipids in the cell membrane altering cell wall permeability causing a loss in essential intracellular elements.