Crotamiton + Permethrin
Indications
Crotamiton + Permethrin is used for:
Pruritus, Scabies
Adult Dose
Adults: Apply once. If necessary, a second application may be given not less than 7 days after the initial application.
Child Dose
Children aged 2 months to 2 years: Apply over whole body under doctor supervision.
Renal Dose
Administration
Lotion should be applied to clean, dry skin. If the body is hot due to warm bath or any other reason, skin should be allowed to cool. It should be applied to the whole body excluding head. The whole body should be washed thoroughly 8-12 hours after treatment. On the next day cloths and bed sheets should be cleaned with warm water. The lotion should be applied if lotion is washed out by water. Other members of the family should use this lotion as preventive in the same way due to its highly contagious effects. The lotion should not be applied to the vicinity of mouth and areas close to eyes.
Contra Indications
Permethrin is contraindicated in subjects with known hypersensitivity to the Product.
Precautions
Avoid contact with eyes and mucous membranes. Cross-sensitivity may occur with ragweed or chrysanthemums. History of asthma. Pregnancy and lactation.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Crotamiton + Permethrin :
Generally mild and transient burning and stinging are followed by application of lotion. Other temporary symptoms of irritation including pruritus, erythema, numbness, eczema and rash may occur. In patients itching may persist for up to 4 weeks Post-treatment. This is generally regarded as due to an allergic reaction to the dead mites under the skin and is not necessarily indicative of a treatment failure.
Mechanism of Action
Crotamiton has scabicidal and antipruritic action against Sarcoptes scabei. It is an effective pediculocide as well.
Permethrin is a pyrethroid pediculocide and scabicide. It causes paralysis and death of the pest by inhibiting sodium ion influx through nerve cell membrane channels delaying repolarisation.