Desoximetasone
Indications
Desoximetasone is used for:
Corticosteroid-responsive dermatoses
Adult Dose
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.05-0.25% cream/gel/lotion/oint: Apply a thin film onto affected area bid. Rub in gently.
Child Dose
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Child: As 0.05-0.25% cream/gel/lotion/oint: Apply a thin film onto affected area bid. Rub in gently.
Renal Dose
Administration
Contra Indications
Hypersensitivity
Precautions
Childn. Pregnancy and lactation. Patient Counselling Avoid use of occlusive dressings. Topical spray is flammable, avoid exposure to heat and flame or smoking during or immediately after application.
Monitoring Parameters Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression through ACTH stimulation or urinary free cortisol test.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
Interactions
May diminish the antineoplastic effect of aldesleukin. May potentiate the hyperglycaemic effect of ceritinib. May diminish the therapeutic effect of corticorelin and hyaluronidase. May enhance the adverse/toxic effects of deferasirox.
Adverse Effects
Side effects of Desoximetasone :
Frequency Not Defined
Skin atrophy
Striae
Acneform lesions
Pruritus
Irritation
Miliaria
Folliculitis
Erythema
Hypopigmentation
Vesiculation
Pigmentation changes
HPA suppression (with higher potency used >2 wk)
Mechanism of Action
Desoximetasone is a topical corticosteroid that induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid hence depresses the formation, release, and activity of endogenous chemical mediators such as kinins, histamine, liposomal enzymes, and prostaglandins.