Dexamethasone + Moxifloxacin eye prep
Indications
Dexamethasone + Moxifloxacin eye prep is used for:
Treatment of ocular infections caused by susceptible microorganisms.
Prevention of inflammation & bacterial infection after ocular surgery.
Steroid-responsive inflammatory ocular conditions
Adult Dose
Ophthalmic
One or two drops instilled into the conjunctival sac(s), every 4 to 6 hours. During the initial 24 to 48 hours.
The dosage may be increased to 1 or 2 drops every two hours.
Frequency must be decreased gradually or warranted by improvement in clinical signs. Care should be taken not to discontinue the therapy prematurely.
Child Dose
Renal Dose
Administration
Contra Indications
This eye drop is contraindicated in epithelial herpes simplex keratitis (Dendritic keratitis), vaccinia, varicella, and in many other viral diseases of the conjunctiva and cornea, Mycobacterial infection of the eye and fungal diseases of ocular structures and in individuals hypersensitive to any of the components of the medication.
Precautions
Prolonged use of steroids may result in glaucoma with damage to the optic nerve, defects in visual acuity and fields of vision, and posterior subcapsular cataract formation.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Dexamethasone + Moxifloxacin eye prep :
The most frequently reported drug-related undesirable effects seen with moxifloxacin are conjunctival irritation, increased lacrimation, keratitis and papillary conjunctivitis. Secondary Infection
Mechanism of Action
Dexamethasone is a synthetic glucocorticoid which decreases inflammation by inhibiting the migration of leukocytes and reversal of increased capillary permeability. It suppresses normal immune response.
Moxifloxacin inhibits the topoisomerase II (DNA gyrase) and topoisomerase IV required for bacterial DNA replication, transcription, repair and recombination.