Dexibuprofen

Indications

Dexibuprofen is used for: Osteoarthritis, Pain, Fever, Pericarditis, Dysmenorrhea, Rheumatic disorders, Patent ductus arteriosus

Adult Dose

Oral Pain and inflammation associated with musculoskeletal and joint disorders ; Dysmenorrhoea Adult: 600-900 mg daily in 2-3 divided doses. May increase to 1200 mg daily for patients with acute conditions or exacerbations. Max Dosage: 400 mg/dose and 1200 mg/day. Hepatic impairment: Dose reduction is recommended.

Child Dose

Renal Dose

Renal impairment: Dose reduction is recommended.

Administration

Contra Indications

Hypersensitivity to aspirin or NSAIDs; active or suspected GI ulcer or history of recurrent GI ulcer; GI bleeding or other active bleedings or bleeding disorders; active Crohn's disease or ulcerative colitis; haemorrhagic diasthesis and other coagulation disorders, or patients receiving anticoagulant therapy; severe heart failure, renal or hepatic impairment; child <18 yrs; pregnancy (third trimester).

Precautions

History of bronchial asthma; renal or hepatic disorders; bleeding disorders; CV disease; elderly; lactation.

Pregnancy-Lactation

Interactions

Avoid concomitant use with anticoagulants, other NSAIDs and salicylates. Increases risk of methotrexate and lithium toxicity.

Adverse Effects

Side effects of Dexibuprofen : GI bleeding, heartburn, epigastric pain; dyspepsia, peptic ulcer; nausea, vomiting, diarrhoea; jaundice, hepatitis; rash; thrombocytopaenia; visual disturbances; tinnitus; depression; fatigue, headache, dizziness, vertigo.

Mechanism of Action

Dexibuprofen is a NSAID. It acts by inhibition of cyclo-oxygenase, which is involved in prostaglandin synthesis.