Dexrabeprazole Sodium
Indications
Dexrabeprazole Sodium is used for:
Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Adult Dose
Oral
Adult Usual dose: 10 mg once daily in the morning for 4 to 8 weeks depending upon response of patient.
Maintenance of healing of GERD may suffice with a lower dose of 5 mg once daily.
Child Dose
Renal Dose
Administration
Dexrabeprazole sodium tablets should not be chewed or crushed, but should be swallowed whole.
Contra Indications
Hypersensitivity to dexrabeprazole
Precautions
General: Symptomatic response to therapy does not preclude the presence of gastric malignancy. Pregnancy.
lactation: Since many drugs are excreted in milk, caution should be exercised when Dexrabeprazole sodium is administered to a nursing mother.
Pregnancy-Lactation
Interactions
No clinically significant interactions with drugs metabolized by the CYP450 system. An interaction with compounds (e.g. Ketoconazole) which are dependent on gastric pH for absorption may occur due to the magnitude of acid suppression.
Adverse Effects
Side effects of Dexrabeprazole Sodium :
Headache, diarrhoea, abdominal pain, asthenia, flatulence, rash & dry mouth.
Mechanism of Action
Dexrabeprazole is the chirally pure R (+) enantiomer of racemate Rabeprazole. Dexrabeprazole is a proton pump inhibitor.