Dextromethorphan Hydrobromide
Indications
Dextromethorphan Hydrobromide is used for:
Cough suppression, Flu, Common cold
Adult Dose
Oral
Cough suppressant
Adults (>12 years of age): 10-20 mg (1-2 teaspoonful) every 4 hours, or 30 mg (3 teaspoonful) every 6-8 hours.
Do not exceed 120 mg (12 teaspoonful) in 24 hours.
Child Dose
Oral
Cough suppressant
Children
6 to 12 years of age: 5-10 mg (1/2-1 teaspoonful) every 4 hours, or 15 mg (11/2 teaspoonful) every 6-8 hours. Do not exceed 60 mg (6 teaspoonful) in 24 hours.
2 to 6 years of age: 2.5-5 mg (1/4-1/2 teaspoonful) every 4 hours, or 7.5 mg (3/4 teaspoonful) every 6-8 hours. Do not exceed 30 mg (3 teaspoonful) in 24 hours.
<2 years of age: Use only as directed by the physician.
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity to Dextromethorphan or any other component.
Precautions
Do not use Dextromethorphan to control a cough that is associated with smoking, asthma, or emphysema, or a cough that is productive (produces sputum or phlegm).
Lactation: Not known if excreted in breast milk; use caution
Pregnancy-Lactation
Pregnancy category: C
Lactation: Not known if excreted in breast milk; use caution
Interactions
Dextromethorphan: Tricyclic antidepressants (TCAs), antipsychotics, anxiolytics and hypnotics, cimetidine, ciprofloxacin, domperidone, metoclopramide, mexiletine, CYP2D6 inhibitors, ritonavir, alcohol.
Potentially Fatal: Memantine, moclobemide.
Adverse Effects
Side effects of Dextromethorphan Hydrobromide :
Common
Nausea, Vomiting, Constipation, Drowsiness, Dizziness, Sedation, Confusion, Nervousness
Mechanism of Action
Dextromethorphan is a centrally acting cough suppressant which acts on the cough centre in the medulla.