Dextromethorphan + Pseudoephedrine Hydrochloride +Triprolidine Hydrochloride
Indications
Dextromethorphan + Pseudoephedrine Hydrochloride +Triprolidine Hydrochloride is used for:
Flu, Colds, Runny nose, Dry coughs, Non-productive cough, Nasal congestion
Adult Dose
Oral
Cough and common cold
Adult: 2 teaspoonful three times a day.
Child Dose
Children
Over 12 years 2 teaspoonful three times a day
6-12 years 1 teaspoonful three times a day
2-6 years 1/2 teaspoonful three times a day or
as directed by the physician
Renal Dose
Administration
Contra Indications
Patients at risk of developing resp failure. During an acute attack. Patients receiving MAOI or for 2 wk after discontinuing them. Persistent or chronic cough.
Precautions
3rd trimester of pregnancy; atopic childn; child <1 yr; sedated or debilitated patients; patients confined to supine position; history of asthma. Moderate to severe renal impairment; liver disease.
Pregnancy-Lactation
Interactions
Dextromethorphan: Tricyclic antidepressants (TCAs), antipsychotics, anxiolytics and hypnotics, cimetidine, ciprofloxacin, domperidone, metoclopramide, mexiletine, CYP2D6 inhibitors, ritonavir, alcohol.
Potentially Fatal: Memantine, moclobemide.
Triprolidine + Pseudoephedrine: Increased BP with other sympathomimetic agents (e.g. decongestants, TCA, appetite suppressants). Reduced hypotensive effects of methyldopa, ?- and ?-adrenergic blockers. Increased side effects (e.g. somnolence, agitation) with atomoxetine.
Potentially Fatal: Increased risk of hypertensive crisis with furazolidine, avoid concurrent use. Increased risk of hypertensive crisis with MAOIs; avoid concurrent use or within 2 wk after stopping MAOIs. Increased risk of psychosis with bromocriptine.
Adverse Effects
Side effects of Dextromethorphan + Pseudoephedrine Hydrochloride +Triprolidine Hydrochloride :
Dizziness, GI disturbances.
Mechanism of Action
Triprolidine is a potent competitive histamine H1-receptor antagonist with mild sedating and antimuscarinic properties. Pseudoephedrine, an alpha- and beta-adrenergic receptor agonist, mediates vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa. Dextromethorphan is a centrally acting cough suppressant which acts on the cough centre in the medulla.