Diacerein + Glucosamine Sulphate
Indications
Diacerein + Glucosamine Sulphate is used for:
Rheumatoid arthritis, Osteoarthritis, Chronic low back pain
Adult Dose
Oral
Osteoarthritis
Adults:
1 tablet twice daily
Child Dose
Oral
Osteoarthritis
Children over 12 years and older:
1 tablet twice daily
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<30 25 mg daily.
Administration
Should be taken with food. Take w/ or immediately after meals.
Contra Indications
Absorption of Diacerein is reduced if taken with aluminium and/or magnesium hydroxide antacid. Diacerein also increases risk of diarrhea if taken with laxatives, antibiotics. Avoid co-administration with fibers and phytic acids. Diacerein has shown hypersensitivity to anthraquinone derivatives.
Precautions
Caution should be practiced when administering Diacerein + Glucosamine Sulphate in those patients who are allergic to Glucosamine and/or Diacerein or to shellfish (e.g., shrimp, crab); who have diabetes, asthma, alcohol dependence or liver disease. Before taking Diacerein + Glucosamine Sulphate complete blood count, liver function and urinalysis should be monitored regularly.
Pregnancy-Lactation
Interactions
Diacerein: Decreased absorption with aluminium and/or magnesium hydroxide antacids. Increased risk of diarrhoea with laxatives, antibiotics. Avoid co-admin with fibres and phytates.
Glucosamine: May reduce effect of antidiabetic agents, doxorubicin, etoposide, tenoposide. May enhance anticoagulant activity of warfarin.
Adverse Effects
Side effects of Diacerein + Glucosamine Sulphate :
Diarrhea, constipation, epigastric pain, heart burn, nausea, vomiting, headache, skin rashes, drowsiness, intense yellow coloring of urine.
Mechanism of Action
Diacerein is an anthraquinone derivative that has been used in osteoarthritis. It is thought to act via inhibition of interleukin-1. Glucosamine stimulates the production of proteoglycans and increases sulfate uptake by articular cartilage.