Dicycloverine Hydrochloride
Indications
Dicycloverine Hydrochloride is used for:
Gastrointestinal tract spasm, Intestinal hypermotility, Irritable bowel syndrome (IBS)
Adult Dose
Oral
Tablet/Syrup
Gastrointestinal tract spasm
Adult: 10-20 mg tid.
Intramuscular
Gastrointestinal tract spasm
Adult: 20 mg 4 times a day given only for 1-2 days. Replace with oral therapy as soon as possible.
Child Dose
Oral
Tablet/Syrup
Gastrointestinal tract spasm
Child: 2-12 yr: 10 mg tid;
6 mth-2 yr: 5-10 mg 3-4 times daily.
Renal Dose
Administration
May be taken with or without food. May be taken before or after meals.
Contra Indications
Intestinal obstruction; intestinal atony; myasthenia gravis; glaucoma; reflux oesophagitis; infants <6 mth; lactation.
Precautions
Hepatic or renal disease, urinary retention, paralytic ileus, hyperthyroidism, hypertension, congestive heart failure, cardiac tachyarrhythmia, children, elderly, pregnancy.
Pregnancy-Lactation
Interactions
Antagonise the effect of drugs that affect GI motility e.g. metoclopramide. Absorption affected by concurrent admin with antacids.
Adverse Effects
Side effects of Dicycloverine Hydrochloride :
Difficulty in accommodation, exacerbation of glaucoma; tachycardia, palpitations, arrhythmias; urinary retention; restlessness; confusion, excitement, hallucination and delirium.
Potentially Fatal: Respiratory arrest in infants <10 wk.
Mechanism of Action
Dicycloverine HCl relieves smooth muscle spasm in the GI and urinary tract. This effect is partly due to antimuscarinic action and partly direct action on the smooth muscle.