Diflorasone Diacetate 0.05% Topical

Indications

Diflorasone Diacetate 0.05% Topical is used for: Psoriasis, Corticosteroid-responsive dermatoses

Adult Dose

Topical/Cutaneous Corticosteroid-responsive dermatoses Adult: As 0.05% ointment/cream: Apply a thin film over the affected areas 1-4 times daily depending on the severity of the condition.

Child Dose

Safety and efficacy not established

Renal Dose

Administration

Contra Indications

Hypersensitivity.

Precautions

Substantial systemic absorption may lead to reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycaemia and glucosuria. Treatment should be discontinued if there is irritation. Pregnancy and lactation. Lactation: It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in milk. Use with caution.

Pregnancy-Lactation

Pregnancy Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels; more potent corticosteroids shown to be teratogenic after dermal application in laboratory animals; there are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids; topical corticosteroids should be used during pregnancy only if potential benefit justifies potential risk to fetus; drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time Lactation Not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk; because many drugs are excreted in human milk, exercise caution should when administering product to a nursing woman

Interactions

Adverse Effects

Side effects of Diflorasone Diacetate 0.05% Topical : Burning sensation, itching, redness, dryness. Folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin atrophy, striae, miliaria.

Mechanism of Action

Diflorasone diacetate is a corticosteroid that is used topically for its anti-inflammatory, antipruritic and vasoconstrictive actions.