Difluprednate Eye prep

Indications

Difluprednate Eye prep is used for: Ocular inflammation and pain

Adult Dose

Ocular Inflammation & Pain Initate 24 hours postop: Instill one drop into the conjunctival sac of the affected eye 4 times daily beginning 24 hours after surgery and continuing throughout the first 2 weeks of the postoperative period, followed by 2 times daily for a week and then a taper based on the response. Endogenous Anterior Uveitis Instill one drop into the conjunctival sac of the affected eye 4 times daily for 14 days followed by tapering as clinically indicated.

Child Dose

Renal Dose

Administration

Contra Indications

Contraindicated in most active viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal disease of ocular structures.

Precautions

Prolonged use of corticosteroids may result in glaucoma with damage to the optic nerve, defects in visual acuity and fields of vision. Steroids should be used with caution in the presence of glaucoma. If this product is used for 10 days or longer, intraocular pressure should be monitored. Lactation: It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in milk. Use caution.

Pregnancy-Lactation

Pregnancy Category: C Lactation: It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in milk. Use caution.

Interactions

Adverse Effects

Side effects of Difluprednate Eye prep : Increased IOP, Anterior chamber inflammation, Corneal edema, Conjunctival edema, Blepharitis, Cataract, Optic nerve damage, Abnormal healing (after surgery), Local irritation, Punctate keratitis, Hyperemia, Punctate keratitis, Decreased visual acuity, Eye pain, Photophobia

Mechanism of Action

It exhibits anti-inflammatory and immunosuppressive effects by inhibiting the release of various cytokines.