Diloxanide Furoate
Indications
Diloxanide Furoate is used for:
Intestinal amoebiasis
Adult Dose
Oral
Intestinal amoebiasis
Adult: 500 mg tid for 10 days. May repeat course if needed.
Child Dose
Oral
Intestinal amoebiasis
Child: >25 kg: 20 mg/kg daily in 3 divided doses for 10 days, repeated if necessary.
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Caution should be exercised in pregnant and breastfeeding women. Avoid excess dosage.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Diloxanide Furoate :
The frequency of these side-effects is unknown
flatulence, itching, urticaria, vomiting
Mechanism of Action
Diloxanide is a luminal amoebicide which is hydrolysed in the gut, thus releasing the free diloxanide which acts as an amoebicide. It is given alone in asymptomatic cyst passers. For patients with active amoebic infections, it can be administered with a 5-nitroimidazole e.g. metronidazole or tinidazole.