Diloxanide furoate, Metronidazole
Indications
Diloxanide furoate, Metronidazole is used for:
DILOXANIDE
Diloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with other agents such as the nitroimidazoles (eg. Metronidazole) in the treatment of invasive or extraintestinal forms of amebiasis
METRONIDAZOLE
For the treatment of anaerobic infections and mixed infections, surgical prophylaxis requiring anaerobic coverage, clostridium difficile-associated diarrhea and colitis, helicobacter pylori infection and duodenal ulcer disease, bacterial vaginosis, giardia lamblia gastro-enteritis, amebiasis caused by entamoeba histolytica, acne rosacea (topical treatment), and trichomonas infections
Diloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with other agents such as the nitroimidazoles (eg. Metronidazole) in the treatment of invasive or extraintestinal forms of amebiasis
METRONIDAZOLE
For the treatment of anaerobic infections and mixed infections, surgical prophylaxis requiring anaerobic coverage, clostridium difficile-associated diarrhea and colitis, helicobacter pylori infection and duodenal ulcer disease, bacterial vaginosis, giardia lamblia gastro-enteritis, amebiasis caused by entamoeba histolytica, acne rosacea (topical treatment), and trichomonas infections
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Diloxanide furoate, Metronidazole :
Mechanism of Action
DILOXANIDE
Unknown. Diloxanide may inhibit protein synthesis
METRONIDAZOLE
Metronidazole is a prodrug. Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. This reduced metronidazole then covalently binds to dna, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death
Unknown. Diloxanide may inhibit protein synthesis
METRONIDAZOLE
Metronidazole is a prodrug. Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. This reduced metronidazole then covalently binds to dna, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death