Diphenhydramine + Phenylephrine
Indications
Diphenhydramine + Phenylephrine is used for:
Cold/Congestion
Adult Dose
Cold/Congestion
Indicated for symptoms occurring with a cold, hay fever, or other upper respiratory allergies
4 teaspoonfuls (ie, 20 mL) PO q4hr PRN
Child Dose
Cold/Congestion
Indicated for symptoms occurring with a cold, hay fever, or other upper respiratory allergies
<6 years: Do not use
6-12 years: 2 teaspoonfuls (ie, 10 mL) PO q4hr PRN
12 years or older: 4 teaspoonfuls (ie, 20 mL) PO q4hr PRN
Renal Dose
Administration
Contra Indications
Hypersensitivity
Repeated administration in patients with anemia or cardiac, pulmonary, or renal disease
Do not use with MAOIs or for 2 weeks after discontinuing MAOIs
Precautions
Phenylephrine may increase blood pressure
Diphenhydramine
Marked drowsiness may occur; avoid other sedating drugs and alcohol
Paradoxical excitability reaction may occur, especially in children
Caution in narrow angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, or bladder neck obstruction
Pregnancy-Lactation
Pregnancy category: B
Lactation: Drug enters breast milk; contraindicated
Interactions
Adverse Effects
Side effects of Diphenhydramine + Phenylephrine :
Frequency Not Defined
Hypertension
Severe peripheral and visceral vasoconstriction
Reflex tachycardia
Dizziness
Drowsiness
Excitability
Headache
Restlessness
Tremor
GI disturbances
Mechanism of Action
Diphenhydramine: Histamine H1-receptor antagonist
Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue; shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia