Diphtheria Toxoid 30IU + Tetanus Toxoid 60IU + Pertusis + Hepatitis B (Vaccine)
Indications
Diphtheria Toxoid 30IU + Tetanus Toxoid 60IU + Pertusis + Hepatitis B (Vaccine) is used for:
Diphtheria, Tetanus, Pertussis, Hepatitis B in infants
Adult Dose
Child Dose
Immunization
Diphtheria, tetanus, pertussis, hepatitis B
Deep IM inj
Primary vaccination 3 doses of 0.5 mL w/in the 1st 6 mth of life at intervals of at least 4 wk.
Booster dose: Administer during the 2nd yr of life.
Renal Dose
Administration
Contra Indications
Previous encephalopathy after pertussis vaccine; acute severe febrie illness.Hypersensitivity to any component of the vaccine. Childn w/ history of encephalopathy of unknown etiology occurring w/in 7 days following previous vaccination. Do not administer IV.
Precautions
Previous reaction to DTP vaccine; family history of convulsions, SIDS; bleeding disorders; immunosuppression /deficiency; pregnancy, lactation. Postpone vaccination in patients w/ acute severe febrile illness. Should be administered SC in patients w/ thrombocytopenia or bleeding disorders. Syncope, risk of apnea. Temp >40°C, persistent crying lasting >3 hr & collapse or shock-like state w/in 48 hrs; convulsions w/ or w/o fever w/in 3 days. High incidence of pertussis. Childn w/ progressive neurological disorders including infantile spasms, uncontrolled epilepsy or progressive encephalopathy. Consider potential risk of apnea & need for resp monitoring for 48-72 hr to very premature infants (>28 wk of gestation) particularly those w/ previous history of resp immaturity.
Lactation: Not indicated for women of childbearing age
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Not indicated for women of childbearing age
Interactions
Adverse Effects
Side effects of Diphtheria Toxoid 30IU + Tetanus Toxoid 60IU + Pertusis + Hepatitis B (Vaccine) :
>10%
Irritability/fussiness (61-65%), Drowsiness (41-57%), Fever (28-39%), Loss of appetite (26-31%), Swelling (17-29%)
1-10%
Fever (≤1%)
<1%
Anorexia, Apnea, Erythema, Decreased consciousness, Diarrhea, Hypotonia, Encephalitis, Brachial neuritis, Erythema, Peripheral neuropathy, Cough, Lethargy, Limb pain, Liver function test abnormalities, Rash, Restlessness
Mechanism of Action
Vaccine is used for the active immunisation of diphtheria, tetanus and pertussis in children from 6 wk to 6 yr of age. Production of specific antibodies to tetanus, diphtheria, and pertusis (active immunity). Conveys active immunity via stimulation of production of endogenously produced antibodies