Diptheria + tetanus + pertussis + hepatitis B + inactivated polio vaccine + Haemophilus influenza type B (HIB) Vaccine
Indications
Diptheria + tetanus + pertussis + hepatitis B + inactivated polio vaccine + Haemophilus influenza type B (HIB) Vaccine is used for:
Diphtheria, Tetanus, Pertussis, Hepatitis B, Poliomyelitis, HIB
Adult Dose
Child Dose
Primary Immunization
Deep IM inj Primary vaccination 3 or 2 doses of 0.5 mL w/ at least 1-mth interval between doses.
Booster vaccination Given at least 6 mth after last priming dose between 11 & 13 mth of age (after 2 doses) or before 18 mth of age (after 3 doses).
Renal Dose
Administration
Contra Indications
Hypersensitivity. Encephalopathy of unknown etiology occurring w/in 7 days following previous vaccination w/ pertussis-containing vaccine.
Precautions
Hypersensitivity to neomycin & polymyxin. Do not administer intravascularly or intradermally. Postpone vaccination in patients w/ acute severe febrile illness. Temp >40°C, collapse or shock-like state, persistent & inconsolable crying lasting >3 hr w/in 48 hr of vaccination. Convulsions w/ or w/o fever w/in 3 days of vaccination. Progressive neurological disorders including infantile spasms, uncontrolled epilepsy or progressive encephalopathy. Anaphylactic event & syncope may occur. Thrombocytopenia or bleeding disorder. History of febrile convulsions. Consider risk of apnea & resp monitoring for 48-72 hr in very premature infants (>28 wk of gestation) & those w/ history of resp immaturity. False +ve urine tests for HIB infection w/in 1-2 wk after vaccination.
Pregnancy-Lactation
Pregnancy
Not approved for use in individuals >5 years
No human or animal data are available to assess vaccine-associated risks in pregnancy
Lactation
Not approved for use in individuals >5 years
No human or animal data are available to assess the impact on milk production, its presence in breast milk, or its effects on the breastfed infant
Interactions
Adverse Effects
Side effects of Diptheria + tetanus + pertussis + hepatitis B + inactivated polio vaccine + Haemophilus influenza type B (HIB) Vaccine :
Loss of appetite; irritability, abnormal crying, restlessness, nervousness; vomiting, diarrhea; pruritus. Fever, fatigue, inj site reactions including pain, redness, local swelling & induration.
Mechanism of Action
Vaccine is used for the active immunisation of Diphtheria, Tetanus, Pertussis, Hepatitis B, Poliomyelitis & HIB. Production of specific antibodies to tetanus, diphtheria, and pertusis (active immunity). Conveys active immunity via stimulation of production of endogenously produced antibodies