Disodium Hydrogen Phosphate Dodecahydrate 24% + Sodium Dihydrogen Phosphate Dihydrate 54.22%

Indications

Disodium Hydrogen Phosphate Dodecahydrate 24% + Sodium Dihydrogen Phosphate Dihydrate 54.22% is used for: Constipation, Colonoscopy preparation

Adult Dose

Oral Colon cleansing Adult: Diluting the contents of one bottle of the medicine (45ml) in half a glass (120ml) of cold water. Take first dose of Fleet followed by at least one full glass (240ml) of cold water. Take the second dose of Fleet phospho-soda after 12 hours, followed by at least one full glass (240ml) of cold water. Drink more water or clear liquids if you want to, up to midnight.

Child Dose

Renal Dose

Administration

Contra Indications

Contraindicated in patients with a known allergy or hypersensitivity to sodium phosphate salts or any of its ingredients.

Precautions

Each bottle of Fleet must be diluted with water before taking. To avoid dehydration you should make sure that you drink plenty of fluids while taking this medicine and after the procedure. It is important to make sure that you will always have access to a toilet after taking a dose of Fleet phospho-soda, as loose bowel motions can start half an hour after taking it. If you don't have a bowel movement within six hours of your first dose if this medicine you should not take any more and consult your doctor immediately. Patients should be instructed to drink 8 ounces of clear liquids with each 4-tablet dose of Patients should take a total of 2 quarts of clear liquids with this oral prep. Inadequate fluid intake, as with any effective purgative, may lead to excessive fluid loss, hypovolemia, and dehydration. Dehydration from purgation may be exacerbated by inadequate oral fluid intake, vomiting, and/or use of diuretics. Administration of sodium phosphate products prior to colonoscopy for colon cleansing has resulted in fatalities due to significant fluid shifts, severe electrolyte abnormalities, and cardiac arrhythmias. These fatalities have been observed in patients with renal insufficiency, in patients with bowel perforation, and in patients who misused or overdosed sodium phosphate products. It is recommended that patients receiving this be advised to adequately hydrate before, during, and after the use of OsmoPrep. Considerable caution should be advised before OsmoPrep Tablets are used in patients with the following illnesses: severe renal insufficiency (creatinine clearance less than 30 mL/minute), congestive heart failure, ascites, unstable angina, gastric retention, ileus, acute bowel obstruction, pseudo-obstruction of the bowel, severe chronic constipation, bowel perforation, acute colitis, toxic megacolon, gastric bypass or stapling surgery, or hypomotility syndrome.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Disodium Hydrogen Phosphate Dodecahydrate 24% + Sodium Dihydrogen Phosphate Dihydrate 54.22% : Renal Disease, Acute Phosphate Nephropathy, and Electrolyte Disorders, Seizures, Cardiac Arrhythmias.

Mechanism of Action

Sodium phosphate can be used in the management of hypophosphataemia. It also acts as a mild osmotic laxative when given orally as dilute solutions or by the rectal route. Phosphate enemas or concentrated oral solutions are used for bowel cleansing before surgery or endoscopy procedures.