Dithranol 1% Topical
Indications
Dithranol 1% Topical is used for:
Psoriasis
Adult Dose
Topical/Cutaneous
Subacute and chronic psoriasis
Adult: Conventional treatment: Apply onto the affected lesions for a few hr before washing off.
May increase the duration of contact extended to overnight periods or longer.
Protect surrounding unaffected skin by applying white soft paraffin.
Child Dose
Topical/Cutaneous
Subacute and chronic psoriasis
Child: Conventional treatment: Apply onto the affected lesions for a few hr before washing off.
May increase the duration of contact extended to overnight periods or longer.
Protect surrounding unaffected skin by applying white soft paraffin.
Renal Dose
Administration
Contra Indications
Acute or pustular psoriasis. Inflamed skin. Hypersensitivity.
Precautions
Avoid use on face, skin flexures, inner thighs, upper arms and genitals. Avoid contact with eyes and mucous membranes.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Dithranol 1% Topical :
Burning sensation and irritation esp on perilesional skin. Hair and skin discoloration.
Mechanism of Action
Dithranol reduces the mitotic rate and proliferation of epidermal cells in psoriasis by inhibiting DNA replication, cellular respiration and key cellular enzymes.Anti-psoriatic action may be partly through inactivating epidermal 12-lipoxygenase & reducing levels of endothelial cell adhesion molecules which are markedly elevated in psoriasis.