Doravirine, Lamivudine, Tenofovir disoproxil
Indications
Doravirine, Lamivudine, Tenofovir disoproxil is used for:
Doravirine
Doravirine is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adult patients with no prior antiretroviral treatment history [FDA Label].
Lamivudine
For the treatment of HIV infection and chronic hepatitis B (HBV).
Tenofovir
Tenofovir has been shown to be effective against HIV, herpes simplex virus-2, and hepatitis B virus.[A178330] To know more about the specific product indications, please visit the information in the orally available forms of tenofovir, [tenofovir alafenamide] and [tenofovir disoproxil].
Doravirine is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adult patients with no prior antiretroviral treatment history [FDA Label].
Lamivudine
For the treatment of HIV infection and chronic hepatitis B (HBV).
Tenofovir
Tenofovir has been shown to be effective against HIV, herpes simplex virus-2, and hepatitis B virus.[A178330] To know more about the specific product indications, please visit the information in the orally available forms of tenofovir, [tenofovir alafenamide] and [tenofovir disoproxil].
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Doravirine, Lamivudine, Tenofovir disoproxil :
Mechanism of Action
Doravirine
Doravirine is a pyridinone non-nucleoside reverse transcriptase inhibitor of HIV-1 [FDA Label, A38823, A38824]. As reverse transcriptase is the principal virally encoded enzyme with which retroviruses like HIV convert their RNA genomes into DNA for the purposes of proliferation within the host genome of infected cells [A38825], doravirine subsequently functions by inhibiting HIV-1 replication by the non-competitive inhibition of HIV-1 reverse transcriptase (RT) [FDA Label]. Doravirine does not however, inhibit the human cellular DNA polymerases a, f�, and mitochondrial DNA polymerase ? [FDA Label].
Lamivudine
Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination.
Tenofovir
Once tenofovir is activated by a bi-phosphorylation it acts as an antiviral acyclic nucleoside phosphonate. It is a potent inhibitor of the viral reverse transcriptase with an inhibitory constant of approximately 0.022 micromolar.[A18473] Once activated, tenofovir acts with different mechanisms including the inhibition of viral polymerase causing chain termination and the inhibition of viral synthesis.[L6241] All these activities are attained by its competition with deoxyadenosine 5'-triphosphate in the generation of new viral DNA. Once tenofovir is incorporated in the chain, it induces a chain termination which in order inhibits viral replication.[A178330] The safety of tenofovir relies on its low affinity towards the cellular DNA polymerase including the mitochondrial DNA polymerase gamma.[T324]
Doravirine is a pyridinone non-nucleoside reverse transcriptase inhibitor of HIV-1 [FDA Label, A38823, A38824]. As reverse transcriptase is the principal virally encoded enzyme with which retroviruses like HIV convert their RNA genomes into DNA for the purposes of proliferation within the host genome of infected cells [A38825], doravirine subsequently functions by inhibiting HIV-1 replication by the non-competitive inhibition of HIV-1 reverse transcriptase (RT) [FDA Label]. Doravirine does not however, inhibit the human cellular DNA polymerases a, f�, and mitochondrial DNA polymerase ? [FDA Label].
Lamivudine
Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination.
Tenofovir
Once tenofovir is activated by a bi-phosphorylation it acts as an antiviral acyclic nucleoside phosphonate. It is a potent inhibitor of the viral reverse transcriptase with an inhibitory constant of approximately 0.022 micromolar.[A18473] Once activated, tenofovir acts with different mechanisms including the inhibition of viral polymerase causing chain termination and the inhibition of viral synthesis.[L6241] All these activities are attained by its competition with deoxyadenosine 5'-triphosphate in the generation of new viral DNA. Once tenofovir is incorporated in the chain, it induces a chain termination which in order inhibits viral replication.[A178330] The safety of tenofovir relies on its low affinity towards the cellular DNA polymerase including the mitochondrial DNA polymerase gamma.[T324]