Doxylamine + Dextromethorphan
Indications
Doxylamine + Dextromethorphan is used for:
Cough, Rhinorrhea & Sneezing
Adult Dose
Cough, Rhinorrhea & Sneezing
30 mL PO q6hr; not to exceed 4 doses/day
Child Dose
Cough, Rhinorrhea & Sneezing
>12 years: 30 mL PO q6hr; not to exceed 4 doses/day
Renal Dose
Administration
Contra Indications
Hypersensitivity
Asthma attacks
Use of MAO inhibitors within 14 days
< 2 years of age
Narrow-angle glaucoma
Breastfeeding
Symptomatic prostate hypertrophy
Bladder-neck obstruction
Stenosing peptic ulcer
Precautions
Caution in patients < 6 years of age
Doxylamine: Caution in used concomitantly with another CNS deppressatn; may exacerbate angle closure glaucoma, hyperthyroidism, peptic ulcer, or urinary tract obstruction; xerostomia may occur; caution in COPD, cardiovascular disease, asthma, increased intraocular pressure, elderly patients or GI obstruction
Dextromethorphan: Do not take for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; may decrease respiration rate
Pregnancy-Lactation
Pregnancy category: C
Lactation: excreted in breast milk, use caution
Interactions
Adverse Effects
Side effects of Doxylamine + Dextromethorphan :
Common Adverse Effects
Agranulocytosis
Potential for abuse
Leukopenia
Serotonin syndrome
Dizziness
Drowsiness
Thrombocytopenia
Toxic psychosis
GI disturbances
Dry mouth, throat, and nose
Thickening of mucus in nose or throat
Constipation
Blurred vision
Headache
Urinary retention
Mechanism of Action
Doxylamine: Competitively blocks histamine from binding to H1 receptors; significant antimuscarinic activity & penetrates CNS, which causes pronounced tendency to induce sedation
Dextromethorphan: Cough suppressant that acts centrally on the cough center in medulla