Efalizumab
Indications
Efalizumab is used for:
Psoriasis
Adult Dose
Subcutaneous
Psoriasis
Adult: Initially, 0.7 mg/kg; followed by a wkly dose of 1 mg/kg. Treatment period is usually 12 wk, to continue only when there is improvement. Max: 200 mg/dose.
Child Dose
Renal Dose
Administration
Contra Indications
Known hypersensitivity. Should not be used in patients with clinically important infections.
Precautions
Monitor platelet counts before and during treatment. Acellular, live and live-attenuated vaccines should not be given during treatment. Pregnancy and lactation.
Pregnancy-Lactation
Interactions
Avoid concurrent admin of other immunosuppressive agents or with phototherapy.
Adverse Effects
Side effects of Efalizumab :
Headache, fever, nausea, vomiting.
Mechanism of Action
Efalizumab is a recombinant humanized anti-CD11a monoclonal antibody functioning as an immunosuppressive agent used in the management of moderate to severe chronic plaque psoriasis.