Eprosartan

Indications

Eprosartan is used for:

Adult Dose

Oral Hypertension Adult: Initially, 600 mg once daily, adjusted according to response. Maintenance: 400-800 mg/day in 1 or 2 divided doses. Elderly: No dosage adjustment needed. Hepatic impairment: No dosage adjustment needed.

Child Dose

Renal Dose

Renal impairment: Moderate to severe (CrCl <60 mL/min): Max: 600 mg/day.

Administration

May be taken with or without food.

Contra Indications

Concomitant use w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min). Pregnancy.

Precautions

Patients w/ CHF, volume depletion, unstented unilateral or bilateral renal artery stenosis, significant aortic or mitral stenosis. Hepatic and renal impairment. Lactation. Monitoring Parameters Monitor BP, electrolytes, serum creatinine, BUN, K levels.

Pregnancy-Lactation

Pregnancy Category: C (1st trimester); D (2nd & 3rd trimesters). During the second and third trimesters of pregnancy, these drugs have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death Lactation: excretion in milk unknown/not recommended

Interactions

May increase serum lithium levels and toxicity. Additive hyperkalaemic effect when used w/ K-sparing diuretics, K supplements or K-containing salt substitutes. NSAIDs may attenuate antihypertensive effect and result in deterioration of renal function including possible acute renal failure. Potentially Fatal: Increased risk of hypotension, hyperkalaemia and changes in renal function when used w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min).

Adverse Effects

Side effects of Eprosartan : 1-10% Upper respiratory infection (8%) Cough (4%) Abdominal pain (2%) Fatigue (2%) Frequency Not Defined Facial edema Dizziness Headache Neutropenia Back pain Myalgia

Mechanism of Action

Eprosartan blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to AT1 receptor in many tissues (e.g. vascular smooth muscle, adrenal gland).