Erdosteine
Indications
Erdosteine is used for:
Symptomatic treatment of acute exacerbations of, chronic bronchitis, in adults as an expectorant.
Adult Dose
Oral
As a mucolytic
Adult: 300 mg bid. Max duration: 10 days.
Hepatic Failure
Since there are no data in patients with severe liver failure, the use of erdosteine is not recommended in these patients.
Mild to Moderate Hepatic Failure
Dose should be reduced
Child Dose
Renal Dose
Since there are no data in patients with creatinine clearance <25ml/min, the use of erdosteine is not recommended in these patients.
Administration
The capsules must be swallowed whole with a glass of water.
Contra Indications
Hypersensitivity to the active substance or to any of the other excipients. Active peptic ulcer.
Precautions
Pregnancy, lactation.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Erdosteine :
Epigastralgia, nausea, vomiting, loose stools, spasmodic colitis, headache.
Mechanism of Action
Erdosteine contains two sulfhydryl groups, which are freed after metabolic transformation in the liver. The liberated sulfhydryl groups break the disulphide bonds, which hold the glycoprotein fibres of mucus together. This makes the bronchial secretions more fluid and enhances elimination.