Fenticonazole Nitrate 2%

Indications

Fenticonazole Nitrate 2% is used for: Candidiasis, Fungal skin infections, Vaginal thrush (Vaginal candidiasis), Vulvovaginal candidiasis

Adult Dose

Topical Cutaneous fungal infections Adult: Apply 2% cream twice daily on the affected site. Vaginal Tablet Vaginal thrush The VT should be inserted into the vagina as a single dose, at bedtime.

Child Dose

Renal Dose

Administration

Vaginal administration: Insert one VT high into the vagina in the evening before going to bed (this is easiest when lying on back with knees bent up).

Contra Indications

Hypersensitivity;

Precautions

Discontinue if sensitization or irritation occurs. Pregnancy and lactation.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Fenticonazole Nitrate 2% : Local irritation, burning and sensitisation, contact dermatitis, mild and transient erythematous reactions

Mechanism of Action

The main mechanism of action of fenticonazole is based on the inhibition of the synthesis of aspartate acid proteinase, a virulence enzyme of Candida albicans correlated with the adherence of the yeast to epithelial cells. This activity is quite peculiar as it was not observed with fluconazole, ketoconazole and miconazole.