Fluconazole 0.3% Eye prep
Indications
Fluconazole 0.3% Eye prep is used for:
Fungal corneal ulcers, Fungal keratitis, Fungal eye infections
Adult Dose
Adult: 1 - 2 drops to be instilled into the affected eye 5 times daily.
Child Dose
Renal Dose
Administration
Contra Indications
The drug is contraindicated in patients with hypersensitivity to azoles.
Precautions
Use of fluconazole may result in overgrowth of non-susceptible strains of candida other than C. albicans.
Pregnancy-Lactation
Interactions
May increase plasma concentrations of oral hypoglycaemics (e.g. tolbutamide, glyburide, glipizide), phenytoin, theophylline, tofacitinib, rifabutin. May increase prothrombin time w/ anticoagulants. May cause significant increase in ciclosporin levels in renal transplant patients w/ or w/o renal impairment. Rifampicin reduces fluconazole levels. May increase risk of nephrotoxicity w/ tacrolimus. May increase the effect of short-acting benzodiazepines (e.g. midazolam).
Potentially Fatal: Increased risk of cardiac arrhythmias or QT prolongation w/ terfenadine, cisapride, astemizole, pimozide, quinidine, halofantrine and erythromycin.
Adverse Effects
Side effects of Fluconazole 0.3% Eye prep :
This drug is generally well tolerated. Eosinophillia has been reported in some patients.
Mechanism of Action
Fluconazole decreases ergosterol synthesis by interfering w/ cytochrome P450 activity, thus inhibiting cell membrane formation of susceptible fungi including B. dermatitidis, Candida spp., C. immitis, C. neoformans, Epidermophyton spp., H. capsulatum, Micosporum spp., Trichophyton spp.