Fluocinolone 0.025% + Neomycin Sulphate 0.5% Topical
Indications
Fluocinolone 0.025% + Neomycin Sulphate 0.5% Topical is used for:
Psoriasis, Eczema, Tularaemia, Dermatitis,
Adult Dose
Adult: Topical cream/oint: Apply 2-3 times/day.
Child Dose
Renal Dose
Administration
Contra Indications
Primary infectious (bacterial, viral, fungal) ulcers, hypersensitivity, acne vulgaris. Neonates.
Precautions
Children, elderly, hepatic failure. Prolonged use on the face; contact with eyes. Pregnancy, lactation.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Fluocinolone 0.025% + Neomycin Sulphate 0.5% Topical :
Dry skin, pruritus, irritation, mild to moderate transient burning/stinging. Local atrophic changes in the skin (prolonged & intensive treatment). Hypercorticism (systemic absorption on prolonged use). Itching, folliculitis, hypertrichoses, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of skin, secondary infections, striae & miliaria. Ototoxicity & nephrotoxicity.
Prolonged admin causes epidermal thinning, telangiectasia and striae (especially face and flexures). Application on eyelid and surrounding skin can cause raised intraocular pressure, cataracts, glaucoma, corneal ulcers and raised intracranial pressure. Systemic absorption with adrenal suppression may be seen when applied over large areas, when skin is broken or under occlusive dressing.
Mechanism of Action
Fluocinolone acetonide is a synthetic fluorinated corticosteroid that is used topically for its anti-inflammatory, anti-pruritic and vasoconstrictive properties.
Neomycin is an aminoglycoside antibiotic. It binds to 30S ribosomal subunits of bacterial ribosome thus inhibiting protein synthesis and generating errors in genetic code transcription causing cell death. It acts against many gram-negative aerobes and some gram-positive aerobes. It lacks activity against fungi, viruses and most anaerobic bacteria.