Fluocinolone 0.1% + Neomycin Sulphate 0.5% Eye prep

Indications

Fluocinolone 0.1% + Neomycin Sulphate 0.5% Eye prep is used for: Inflammatory eye disorders

Adult Dose

Adult: Apply onto affected eye(s) 3-4 times daily.

Child Dose

Renal Dose

Administration

Contra Indications

Primary infectious (bacterial, viral, fungal) ulcers, hypersensitivity. Neonates.

Precautions

Children, elderly, hepatic failure. Prolonged use. Pregnancy, lactation.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Fluocinolone 0.1% + Neomycin Sulphate 0.5% Eye prep : Prolonged admin causes epidermal thinning, telangiectasia and striae (especially face and flexures). Application on eyelid and surrounding skin can cause raised intraocular pressure, cataracts, glaucoma, corneal ulcers and raised intracranial pressure. Systemic absorption with adrenal suppression may be seen when applied over large areas, when skin is broken or under occlusive dressing.

Mechanism of Action

Fluocinolone acetonide is a synthetic fluorinated corticosteroid that is used topically for its anti-inflammatory, anti-pruritic and vasoconstrictive properties. Neomycin is an aminoglycoside antibiotic. It binds to 30S ribosomal subunits of bacterial ribosome thus inhibiting protein synthesis and generating errors in genetic code transcription causing cell death. It acts against many gram-negative aerobes and some gram-positive aerobes. It lacks activity against fungi, viruses and most anaerobic bacteria.