Fluorouracil
Indications
Fluorouracil is used for:
Carcinomas of the colorectum, breast, stomach, pancreas, cervix, prostate, ovary and endometrium; liver tumours;
Head and neck tumours;
Actinic keratosis
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Pregnancy and breastfeeding
Precautions
Hepatic impairment
Pregnancy-Lactation
Recommendations on the use of Fluorouracil in Pregnancy & Lactation:
Fluorouracil is contraindicated during pregnancy especially during the first trimester as it has been associated with teratogenic effects. Breastfeeding should be avoided in mothers on fluorouracil (Briggs & Freeman, 2015; Schaefer et al., 2015; WHO 2009).
References:
1. Briggs, G. G., & Freeman, R. K. (2015). Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk (Tenth edition). Wolters Kluwer/Lippincott Williams & Wilkins Health.
2. Schaefer, C., Peters, P., & Miller, R. K. (2015). Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment (Third Edition). Academic Press.
3. World Health Organization, Stuart, Marc C, Kouimtzi, Maria & Hill, Suzanne. (2009). WHO model formulary 2008 / editors: Marc C. Stuart, Maria Kouimtzi, Suzanne R. Hill. World Health Organization. https://apps.who.int/iris/handle/10665/44053
Interactions
Adverse Effects
Side effects of Fluorouracil :