Fluticasone Propionate 0.05% Topical

Indications

Fluticasone Propionate 0.05% Topical is used for: Psoriasis, Eczema, Corticosteroid-responsive dermatoses

Adult Dose

Topical cream Atopic Dermatitis, Corticosteroid-responsive Dermatoses Apply a thin film to the affected skin areas once or twice daily. Rub in gently. Reassess diagnosis if no improvements within 2 weeks

Child Dose

Topical cream Atopic Dermatitis, Corticosteroid-responsive Dermatoses Child > 3 months: Apply a thin film to the affected skin areas once or twice daily.

Renal Dose

Administration

Contra Indications

Hypersensitivity. Acne vulgaris, rosacea, perioral dermatitis, skin atrophy; hypersensitivity. Primary cutaneous viral infections (e.g. herpes simplex, chicken pox), perianal and genital pruritus, primary fungal or bacterial skin infections. Inhalation: Status asthmaticus.

Precautions

Children, pregnancy, lactation, concomitant skin infections. Concomitant skin/lung/systemic infections. Advised to rinse mouth with water every time after inhalation. Application to large areas, broken skin or under occlusive dressings. Lactation: Excretion in milk unknown; use with caution

Pregnancy-Lactation

Pregnancy Category: C Lactation: Excretion in milk unknown; use with caution

Interactions

May lead to increased plasma concentrations of fluticasone when used with CYP4503A4 inhibitors such as ritonavir.

Adverse Effects

Side effects of Fluticasone Propionate 0.05% Topical : 1-10% Pruritus (2.9%), Dryness (1.2%), Skin irritation: (3%), Eczema (1%), Telangiectasia (2-5%), Numbness of fingers (1%) <1% Burning, Folliculitis, Acneiform lesions, Urticaria, Hypertrichosis, Lightheadedness, Viral, Warts, Impetigo, Skin infection Frequency Not Defined Striae, Pigmentation changes, HPA suppression (with higher potency used >2 wk), Erythema, Cushing syndrome, Sepsis, Hemorrhage reported, Edema/swelling Potentially Fatal: Suppression of immune system.

Mechanism of Action

Fluticasone utilises a fluorocarbothioate ester linkage at the C17 position. It has potent vasoconstrictive and anti-inflammatory activity, but weak HPA inhibitory effect when applied topically.