Fucidic Acid + Betamethasone Topical
Indications
Fucidic Acid + Betamethasone Topical is used for:
Corticosteriod-responsive dermatoses w/ secondary infection
Adult Dose
Topical/Cutaneous
Corticosteriod-responsive dermatoses with secondary infection
Adult: Apply to the affected area(s) bid. Max duration: 2 wk.
Child Dose
Renal Dose
Administration
Contra Indications
Skin lesions of viral, fungal or bacterial origin, acne rosacea and perioral dermatitis.
Precautions
Avoid prolonged continuous treatment especially in infants and children. Extended treatment may increase the risk of contact sensitisation and development of antibiotic resistance. Not to be used for >7 days if there is no clinical improvement. Increased risk of glaucoma if preparation enters the eye(s). Pregnancy and lactation.
Pregnancy-Lactation
Interactions
Fucidic Acid: Synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin.
Betamethasone : Increased hyperglycaemia and hypokalaemia with thiazide diuretics. Increased incidence of peptic ulcer or GI bleeding with concurrent NSAIDs admin. Response to anticoagulants altered. Dose of antidiabetics and antihypertensives needs to be increased. Decreases serum conc of salicylates and antimuscarinic agents.
Potentially Fatal: Reduced efficacy with concurrent use of carbamazepine, phenytoin, primidone, barbiturates and rifampicin. Enhanced effect in women taking oestrogens or oral contraceptives.
Adverse Effects
Side effects of Fucidic Acid + Betamethasone Topical :
Prolonged intensive treatment may cause local atrophic changes in the skin e.g. striae, thining and dilatation of superficial blood vessels. Dryness, itching, irritation, hypopigmentation, burning sensation at the site of application or miliaria.
Mechanism of Action
Betamethasone valerate is a topical corticosteroid that is effective in inflammatory dermatoses.
Topical fusidic acid is effective against Staphyloccus aureus, Streptococci, Corynebacteria, Neisseria and some Clostridia and bacteroides. Antibacterial activity of fusidic acid is not reduced when used with betamethasone.