Gadodiamide
Indications
Gadodiamide is used for:
Indicated for intravenous use in MRI to visualize lesions with abnormal vascularity (or those thought to cause abnormalities in the blood-brain barrier) in the brain (intracranial lesions), spine, and associated tissues
Adult Dose
Adults: The recommended dose is 0.2 mL/kg (0.1 mmol/kg) administered as a bolus intravenous injection.
Child Dose
Pediatric Patients (2-16 years): The recommended dose is 0.2 mL/kg (0.1 mmol/kg) administered as a bolus intravenous injection.
Renal Dose
Administration
Contra Indications
Chronic, severe kidney disease (glomerular filtration rate, GFR < 30 mL/min/1.73m²), or acute kidney injury prior hypersensitivity reaction
Precautions
Gadolinium-based contrast agents (GBCAs) increase the risk for nephrogenic systemic fibrosis (NSF) among patients with impaired elimination of the drugs. Avoid use of GBCAs among these patients unless the diagnostic information is essential and not available with non-contrast enhanced MRI or other modalities.
The GBCA-associated NSF risk appears highest for patients with chronic, severe kidney disease (GFR < 30 mL/min/1.73m²) as well as patients with acute kidney injury.
Screen patients for acute kidney injury and other conditions that may reduce renal function.
Pregnancy-Lactation
Pregnancy
GBCAs cross the placenta and result in fetal exposure and gadolinium retention
Human data on the association between GBCAs and adverse fetal outcomes are limited and inconclusive
Estimated background risk of major birth defects and miscarriage for the indicated population is unknown; because of potential risks of drug to fetus, use drug only if imaging is essential during pregnancy and cannot be delayed
Lactation
There are no data on presence of drug in human milk, effects on breastfed infant or on milk production; estimated infant exposure is 0.001%-0.04% of the maternal dose
Unknown whether the effects of the drug on the breastfed infant or the effects of the drug on milk production
Developmental and health benefits of breastfeeding should be considered together with the mother’s clinical need for the drug and any potential adverse effects on the breastfed infant or from underlying maternal condition
Interactions
Adverse Effects
Side effects of Gadodiamide :
Nephrogenic systemic fibrosis, Hypersensitivity reactions