Gentamicin 0.3% Topical

Indications

Gentamicin 0.3% Topical is used for: Bacterial skin infections, Burns, eczema, seborrheic dermatitis, ecthyma, excoriation, folliculitis, furunculosis, insect bites and stings, lacerations and abrasions, paronychia, pyoderma gangrenosum, skin cysts and abscesses, stasis ulcers and infected skin ulcers, bacterial, fungal or viral superinfection, sycosis barbae, minor surgical wounds, infected contact dermatitis caused by susceptible organisms.

Adult Dose

Adult: Apply to the affected area 3-4 times daily.

Child Dose

Child> 1 year: Apply to the affected area 3-4 times daily.

Renal Dose

Administration

Contra Indications

History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, skin rash.

Precautions

Concurrent use of neuromuscular blocking agents; myasthenia gravis, parkinsonism; conditions predisposing to ototoxicity and nephrotoxicity; lactation. Monitor plasma concentrations of gentamicin in patients receiving high doses or prolonged courses, in infants, elderly, patients with renal impairment, cystic fibrosis or significant obesity. Monitor auditory and renal functions. Lactation: excreted in breast milk; no adverse effect on nursing infant

Pregnancy-Lactation

Pregnancy Category: C Lactation: excreted in breast milk; no adverse effect on nursing infant

Interactions

Synergistic with ampicillin, benzylpenicillin and other ?-lactam antibiotics. Increased risk of severe respiratory depression when used concurrently with anaesthetics or opioids. May reduce renal clearance of zalcitabine and induce hypocalcaemia when used with biphosphonates. Not to be used with agalsidase alfa or beta as it may inhibit alpha-galactosidase activity. Potentially Fatal: Increased incidence of ototoxicity when combined with ethacrynic acid and furosemide. Cephalosporins, ciclosporin, cisplatin, vancomycin, hydrocortisone and indometacin potentiate nephrotoxicity. Potentiates neuromuscular blocking agents.

Adverse Effects

Side effects of Gentamicin 0.3% Topical : Allergic contact dermatitis, Erythema, Pruritus

Mechanism of Action

Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.