Gentamicin (as sulphate), Dexamethasone sodium phosphate
Indications
Gentamicin (as sulphate), Dexamethasone sodium phosphate is used for:
GENTAMICIN
For treatment of serious infections caused by susceptible strains of the following microorganisms: p. Aeruginosa, proteus species (indole-positive and indole-negative), e. Coli, klebsiella-enterobactor-serratia species, citrobacter species and staphylococcus species (coagulase-positive and coagulase-negative)
DEXAMETHASONE
injection: for the treatment of endocrine disorders, rheumatic d=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.
ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.
ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus
topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy
intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps
For treatment of serious infections caused by susceptible strains of the following microorganisms: p. Aeruginosa, proteus species (indole-positive and indole-negative), e. Coli, klebsiella-enterobactor-serratia species, citrobacter species and staphylococcus species (coagulase-positive and coagulase-negative)
DEXAMETHASONE
injection: for the treatment of endocrine disorders, rheumatic d=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.
ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.
ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus
topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy
intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Gentamicin (as sulphate), Dexamethasone sodium phosphate :
Mechanism of Action
GENTAMICIN
Aminoglycosides like gentamicin "irreversibly" bind to specific 30s-subunit proteins and 16s rrna. Specifically gentamicin binds to four nucleotides of 16s rrna and a single amino acid of protein s12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16s rrna of 30s subunit. This region interacts with the wobble base in the anticodon of trna. This leads to interference with the initiation complex, misreading of mrna so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes
DEXAMETHASONE
Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to dna elements (glucocorticoid response elements) which results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase a2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes
Aminoglycosides like gentamicin "irreversibly" bind to specific 30s-subunit proteins and 16s rrna. Specifically gentamicin binds to four nucleotides of 16s rrna and a single amino acid of protein s12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16s rrna of 30s subunit. This region interacts with the wobble base in the anticodon of trna. This leads to interference with the initiation complex, misreading of mrna so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes
DEXAMETHASONE
Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to dna elements (glucocorticoid response elements) which results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase a2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes