Gentamicin (sulphate), Tetryzoline HCl
Indications
Gentamicin (sulphate), Tetryzoline HCl is used for:
GENTAMICIN
For treatment of serious infections caused by susceptible strains of the following microorganisms: p. Aeruginosa, proteus species (indole-positive and indole-negative), e. Coli, klebsiella-enterobactor-serratia species, citrobacter species and staphylococcus species (coagulase-positive and coagulase-negative)
TETRYZOLINE
For temporary relief of discomfort and redness of the eye due to minor eye irritations
For treatment of serious infections caused by susceptible strains of the following microorganisms: p. Aeruginosa, proteus species (indole-positive and indole-negative), e. Coli, klebsiella-enterobactor-serratia species, citrobacter species and staphylococcus species (coagulase-positive and coagulase-negative)
TETRYZOLINE
For temporary relief of discomfort and redness of the eye due to minor eye irritations
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Gentamicin (sulphate), Tetryzoline HCl :
Mechanism of Action
GENTAMICIN
Aminoglycosides like gentamicin "irreversibly" bind to specific 30s-subunit proteins and 16s rrna. Specifically gentamicin binds to four nucleotides of 16s rrna and a single amino acid of protein s12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16s rrna of 30s subunit. This region interacts with the wobble base in the anticodon of trna. This leads to interference with the initiation complex, misreading of mrna so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes
TETRYZOLINE
Tetryzoline is an alpha-adrenergic agonist. Its primary action is the constriction of conjunctival blood vessels, which serves to decrease eye redness caused by minor ocular irritants
Aminoglycosides like gentamicin "irreversibly" bind to specific 30s-subunit proteins and 16s rrna. Specifically gentamicin binds to four nucleotides of 16s rrna and a single amino acid of protein s12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16s rrna of 30s subunit. This region interacts with the wobble base in the anticodon of trna. This leads to interference with the initiation complex, misreading of mrna so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes
TETRYZOLINE
Tetryzoline is an alpha-adrenergic agonist. Its primary action is the constriction of conjunctival blood vessels, which serves to decrease eye redness caused by minor ocular irritants