Glycerol

Indications

Glycerol is used for: Constipation, used as a, personal lubricant for sexual intercourse, use to eases the, discomfort of vaginal dryness during sex.

Adult Dose

Constipation As suppository: Adults: only one 2.30 gm Suppository per 24 hours Personal Lubrication with or without latex condoms As Jelly Apply desired amount of lubricant to intimate areas as required. Reapply as needed.

Child Dose

Constipation As suppository: Children (2 to 6 years): only one 1.15gm Suppository per 24 hours. Children (From 6 years): only one 2.30gm Suppository per 24 hours.

Renal Dose

Administration

Lubricant Apply desired amount of lubricant to intimate areas as required. Reapply as needed. Suppository Insert suppository well up into rectum. Suppository need to melt completely to produce laxative action.

Contra Indications

Hypersensitivity.

Precautions

Hypervolaemia, cardiac failure or renal disease, dehydrated patients, DM. Use of personal lubricants that contain glycerol may trigger yeast infections in women who are prone to them.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Glycerol : Local irritation e.g. rectal discomfort and burning sensation. Few allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); new or worsening skin irritation may occur.

Mechanism of Action

Glycerol is an osmotic dehydrating agent that possesses hygroscopic and lubricating properties. It causes plasma osmolality leading to the movement of water into the plasma from the extravascular spaces via osmosis. Personal lubricant reduces friction during intercourse.