Heparin calcium
Indications
Heparin calcium is used for:
Unfractionated heparin is indicated for prophylaxis and treatment of venous thrombosis and its extension, prevention of post-operative deep venous thrombosis and pulmonary embolism and prevention of clotting in arterial and cardiac surgery. In cardiology, it is used to prevent embolisms in patients with atrial fibrillation and as an adjunct antithrombin therapy in patients with unstable angina and/or non-q wave myocardial infarctions (i. E. Non-st elevated acute coronary artery syndrome) who are on platelet glycoprotein (iib/iiia) receptor inhibitors. Additionally, it is used to prevent clotting during dialysis and surgical procedures, maintain the patency of intravenous injection devices and prevent in vitro coagulation of blood transfusions and in blood samples drawn for laboratory values
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Heparin calcium :
Mechanism of Action
Under normal circumstances, antithrombin iii (atiii) inactivates thrombin (factor iia) and factor xa. This process occurs at a slow rate. Administered heparin binds reversibly to atiii and leads to almost instantaneous inactivation of factors iia and xa the heparin-atiii complex can also inactivate factors ix, xi, xii and plasmin. The mechanism of action of heparin is atiii-dependent. It acts mainly by accelerating the rate of the neutralization of certain activated coagulation factors by antithrombin, but other mechanisms may also be involved. The antithrombotic effect of heparin is well correlated to the inhibition of factor xa. Heparin is not a thrombolytic or fibrinolytic. It prevents progression of existing clots by inhibiting further clotting. The lysis of existing clots relies on endogenous thrombolytics