Hydrocortisone 1% + Miconazole Nitrate 2% Topical
Indications
Hydrocortisone 1% + Miconazole Nitrate 2% Topical is used for:
Topical application to inflammatory skin condition where fungal infecton is present.
Adult Dose
Topical
Skin fungal infections
As cream/ointment: Apply twice daily, not exceeding more than 7 days.
Child Dose
Renal Dose
Administration
Contra Indications
The drug is contraindicated in individuals with a history of sensitivity reactions to Miconazole or any of the components of the preparation, viral disease of the skin (herpes, chickenpox), perioral dermatitis, rosaceae, ulcerative conditions, tuberculous or syphilitic processes.
Precautions
For external use only; discontinue if sensitization or irritation occurs. It should be used with caution when applied to extensive surface areas or under occlusive dressings including baby napkins. Application to the face should be avoided.
Pregnancy-Lactation
Interactions
Oral anticoagulants eg, warfarin. Certain oral hypoglycemics & phenytoin. Hydrocortisone.
Adverse Effects
Side effects of Hydrocortisone 1% + Miconazole Nitrate 2% Topical :
Generally it is well tolerated. An allergic reaction to any of the ingredient of the cream may occur. Rarely, irritation & burning may occur.
Mechanism of Action
Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It may also be used as replacement therapy in adrenocortical insufficiency.
Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.