Hydrocortisone + Benzyl Benzoate + Bismuth Subgallate + Bismuth Oxide + Balsam Peru + Zinc Oxide rectal
Indications
Hydrocortisone + Benzyl Benzoate + Bismuth Subgallate + Bismuth Oxide + Balsam Peru + Zinc Oxide rectal is used for:
Haemorrhoids, Pruritus ani
Adult Dose
Topical
Apply sparingly to the affected area at night, in the morning and after each evacuation up to a maximum of 4 applications a day.
Use for a maximum period of one week.
Child Dose
Renal Dose
Administration
Thoroughly cleanse the affected area, dry and apply ointment on a gauze dressing. For internal conditions use rectal nozzle provided. Remove the nozzle cap. Clean the nozzle after each use.
Contra Indications
Tubercular, fungal and most viral lesions including herpes simplex, vaccinia and varicella. Hypersensitivity to the active substance(s) or to any of the excipients.
Do not use in pregnancy or breast-feeding.
Precautions
Prolonged or excessive use may produce systemic corticosteroid effects and use for periods longer than seven days is not recommended.
Pregnancy-Lactation
There is inadequate evidence of safety in human pregnancy and there may be a very small risk of cleft palate and intrauterine growth retardation as well as suppression of the neonatal hypothalamic-pituitary-adrenal axis. There is evidence of harmful effects in animals.
Do not use in pregnancy or breastfeeding.
Interactions
Concurrent use with other corticosteroid preparations, either topically or orally may increase the likelihood of systemic effects.
Co-treatment with CYP3A inhibitors, including cobicistat containing products, is expected to increase the risk of systemic effects.
Adverse Effects
Side effects of Hydrocortisone + Benzyl Benzoate + Bismuth Subgallate + Bismuth Oxide + Balsam Peru + Zinc Oxide rectal :
Hypersensitivity, Application site reactions, Blurred Vision, Erythema, Exfoliation, Irritation, Pain, Pruritus, Rash and Urticaria
Mechanism of Action
Bismuth oxide, zinc oxide, and bismuth subgallate exert a protective action on mucous membranes and raw surfaces.
They are mildly astringent and are reported to have antiseptic properties.
Balsam Peru has protective properties and a very mild antiseptic action by virtue of its content of cinnamic and
benzoic acids. It is believed to promote the growth of epithelial cells.
Benzyl benzoate is used as a solubilizing agent and has mild antiseptic and preservative properties.
Hydrocortisone acetate has the general properties of hydrocortisone and the anti- inflammatory action is of primary
interest in this product.