Hydrocortisone rectal
Indications
Hydrocortisone rectal is used for:
Ulcerative Proctitis
Adult Dose
Ulcerative Proctitis
Application to distal rectum in patients who cannot retain steroid enemas
Foam
1 applicatorful PR once daily or q12hr for 2-3 weeks, then every other day if necessary; use lowest dosage that maintains clinical response; discontinue if no proctologic improvement is noted after 2-3 weeks
1 applicatorful = 900 mg; contains 90 mg hydrocortisone acetate (= 80 mg hydrocortisone)
Suspension
1 enema at bedtime for 21 days or until remission is achieved; 2-3 months of therapy may be required; taper to discontinue long-term therapy; improvement in mucosal integrity may be preceded by clinical improvement
Child Dose
Renal Dose
Administration
Contra Indications
Documented hypersensitivity
Systemic fungal infections
Ileostomy during immediate or early postoperative period
Obstruction, abscess, perforation, peritonitis, fresh intestinal anastomoses, extensive fistulas
Precautions
Always follow directions for use on product carton
Do not insert any part of aerosol container directly into anus
Sigmoidoscopy is recommended for judging treatment course, rather than symptomatic improvement
Pregnancy-Lactation
Pregnancy category: C
Lactation: Use with caution
Interactions
Adverse Effects
Side effects of Hydrocortisone rectal :
Frequency Not Defined
Burning
Dryness
Folliculitis
Hypopigmentation
Itching
Pain
Rectal bleeding
Secondary infection
Mechanism of Action
Decreases inflammation by suppressing migration of polymorphonuclear leukocytes (PMNs) and reversing increased capillary permeability