Interferon-gamma (human, recombinant)
Indications
Interferon-gamma (human, recombinant) is used for:
Interferon gamma-1b is used for the treatment of Chronic granulomatous disease and Osteopetrosis.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Interferon-gamma (human, recombinant) :
Mechanism of Action
Binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.