Ivermectin topical
Indications
Ivermectin topical is used for:
Indicated for topical treatment of, head lice infestation, also Indicated for inflammatory lesions caused by, rosacea
Adult Dose
Topical/Cutaneous
Head pediculosis
Adult: As 0.5% lotion: Apply sufficient amount into dry hair and scalp as single dose, then leave on for 10 min before rinsing.
Rosacea
Adult: As 1% cream: Apply onto affected area(s) once daily for up to 4 mth, repeat treatment course if needed.
Child Dose
Topical/Cutaneous
Head pediculosis
Child: >6 mth As 0.5% lotion: Apply sufficient amount into dry hair and scalp as single dose, then leave on for 10 min before rinsing.
Renal Dose
Administration
Administration instructions for lice
For topical use only
Avoid contact with eyes
Use lotion in context of an overall lice management program including hot-water washing or dry-cleaning of all recently worn clothing and linens
Wash personal care items (eg, combs, brushes, hair clips)
A fine tooth comb or nit comb may be used to remove dead lice and nits
Rosacea
Use a pea-size amount for each area of the face (forehead, chin, nose, each cheek) that is affected
Spread as a thin layer, avoiding the eyes and lips
Contra Indications
Hypersensitivity
Precautions
To prevent ingestion, administer to children only with direct adult supervision
Not for oral, ophthalmic or intravaginal use
Lactation: Following oral administration, ivermectin is excreted in human milk in low concentrations; excretion following topical administration has not been evaluated
Pregnancy-Lactation
Pregnancy Category: C; no comparisons of animal exposure with human exposure are available with topical ivermectin because of low systemic absorption
Lactation: Following oral administration, ivermectin is excreted in human milk in low concentrations; excretion following topical administration has not been evaluated
Interactions
Adverse Effects
Side effects of Ivermectin topical :
<1%
Conjunctivitis
Ocular hyperemia
Eye irritation
Dandruff
Dry skin
Skin burning sensation
Mechanism of Action
Pediculicide derived from fermentation of a soil dwelling actinomycete, Streptomyces avermitilis
Causes parasite death by selective, high-affinity binding to glutamate-gated chloride channels located in invertebrate nerve and muscle cells; this results in increased cell membrane permeability to chloride ions with hyperpolarization of the nerve or muscle cells, and ultimately parasite paralysis and death
The mechanism by which ivermectin topical treats rosacea lesions is unknown