Lincomycin

Indications

Lincomycin is used for: Severe anaerobic infections

Adult Dose

Intravenous Severe anaerobic infections Adult: IM: 600 mg q12-24hr IV: 600-1000 mg q8-12hr; not to exceed 8 g/day

Child Dose

Intravenous Severe anaerobic infections Child: <1 month old Safety & efficacy not established >1 month old IV: 10-20 mg/kg/day divided q8-12hr IM: 10 mg/kg q12-24hr

Renal Dose

Renal Impairment, severe: 25-30% of usual dose

Administration

IV Preparation 1000 mg should be diluted in 100 mL or more of D5W, D5 in NS, D10W, or NS IV Administration Infusion over 1 hr

Contra Indications

Hypersensitivity to lincomycin or clindamycin

Precautions

Patient w/ history of GI disease particularly colitis, history of asthma or significant allergies. Severe renal and/or hepatic impairment. Pregnancy and lactation. Monitoring Parameters Periodically perform LFTs, kidney function tests and blood cell counts during prolonged therapy.

Pregnancy-Lactation

Pregnancy There are no adequate and well-controlled studies in pregnant women; sterile Solution contains benzyl alcohol as a preservative; benzyl alcohol can cross placenta; should be used during pregnancy only if clearly needed; experience with obstetrical patients receiving drug revealed no ill effects related to pregnancy Animal data No evidence of teratogenicity when drug administered in diet or via oral gavage to pregnant Sprague Dawley rats during period of major organogenesis at doses up to 5000 mg/kg and 100 mg/kg (approximately 6 times and 0.12 times the maximum recommended human dose [MRHD], respectively, based on body surface area comparison) Reproduction studies performed in rats administered drug for 2 weeks prior to mating, throughout pregnancy and lactation, revealed no adverse effects on survival of offspring from birth to weaning at doses up to 1000 mg/kg (1.2 times the MRHD based on body surface area comparison) up to 2 generations Lactation Drug has been reported to appear in human milk in concentrations of 0.5 to 2.4 mcg/mL; because of potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing, or to discontinue drug, taking into account importance of drug to mother

Interactions

May potentiate effects of neuromuscular blocking agents (e.g. pancuronium, tubocurarine). Reduced GI absorption w/ kaolin. May antagonise the effect of erythromycin.

Adverse Effects

Side effects of Lincomycin : Frequency Not Defined Nausea Vomiting Diarrhea Abdominal pain Tenesmus Glossitis Stomatitis Pruritus Angioedema Serum sickness and anaphylactic or anaphylactoid reactions Rash Urticaria Vaginitis Exfoliative/vesiculobullous dermatitis Erythema multiforme Thrombophlebitis Erythema Pain Swelling Transient increases in serum bilirubin, alkaline phosphatase, & AST (SGOT) concentrations Jaundice Transient leukopenia, neutropenia, eosinophilia Thrombocytopenia Agranulocytosis Headache Myalgia Tinnitus Dizziness Vertigo

Mechanism of Action

Lincomycin exerts bacteriostatic and bactericidal effects by binding to 50S ribosome subunit. This results in inhibition of protein synthesis, specifically peptide-bond formation in susceptible organisms.