Lindane topical

Indications

Lindane topical is used for: Scabies, Pediculosis

Adult Dose

Topical/Cutaneous Scabies Adult: Apply a thin layer of 1% topical preparation onto all skin areas from the neck to toes. Completely wash off from the body with warm water after 8-12 hr. Topical/Cutaneous Pediculosis Adult: Apply 30-60 ml of 1% shampoo to dry hair. Amount depends on the length of the hair; most patients will require 30 ml (max 60 ml). Massage into hair for 4 min then add small quantities of water to form a good lather. Immediately rinse thoroughly until all the lather is gone. Dry the hair and comb with a fine tooth comb.

Child Dose

Scabies Lotion: Apply thin layer and massage on skin on entire body except face; bathe and remove drug 8-12 hr after application Head Lice or Crab Lice Apply 1-2 oz of shampoo (not to exceed 2 oz) on dry hair; leave on 4 min, lather, rinse, remove nits with fine comb One time application usually sufficient; may use other pediculicide in 1 wk if necessary

Renal Dose

Administration

Contra Indications

Hypersensitivity. Uncontrolled seizures; broken skin; premature infant. Lactation.

Precautions

Infants, small children, patients <50 kg, history of seizures or conditions which may increase risk of seizures. Hepatic impairment. Avoid contact with face, eyes, mucous membranes and urethral meatus. Pregnancy. Neurotoxicity, including seizures and death, has been reported with repeat or prolonged application, and rarely with single application. Use with caution in those at risk for neurotoxicity including infants, children, elderly persons, those who weigh <50 kg, or those with a history of seizures. It is contraindicated in premature infants and in those with uncontrolled seizure disorders. Counseling the patient on proper use is required. Use only in patients who have failed first line treatments Provide patient with medication use guide with instructions on how to use

Pregnancy-Lactation

Pregnancy Category: C Lactation: distributed in breast milk, do not nurse for 24 hr post-application (express milk & discard)

Interactions

Enhanced absorption and increased risk of toxicity with oils and oil-based preparations. Potentially Fatal: Increased toxicity with drugs that lower seizure threshold e.g. antidepressants, antipsychotics, ciclosporin, isoniazid.

Adverse Effects

Side effects of Lindane topical : Frequency Not Defined Slight local irritation (including eczematous eruptions, rash, conjunctivitis) Repeated application frequently causes contact dermatitis CNS toxicity (seizures) Cardiac arrhythmia Ataxia Dizziness Restlessness Pain Seizure Alopecia Urticaria Hematuria Pulmonary edema Hepatitis Nausea/vomiting Paresthesia Aplastic anemia

Mechanism of Action

Lindane stimulates the nervous system of parasites by direct absorption through their exoskeletons causing seizures and death.