Lynestrenol

Indications

Lynestrenol is used for: Contraception, Menstrual disorders

Adult Dose

Oral Menstrual disorders Adult: 5-10 mg daily as cyclic regimen.

Child Dose

Renal Dose

Administration

May be taken with or without food.

Contra Indications

Undiagnosed vaginal bleeding, active venous thromboembolic disorders or severe arterial disease, hepatic impairment, progestogen-dependent tumours, porphyria. Pregnancy.

Precautions

CV or renal dysfunction, hypertension, epilepsy, migraine, asthma, DM, conditions which may be exacerbated by fluid retention, malabsorption syndrome, post ectopic pregnancy, functional ovarian cysts, thromboembolism. Lactation.

Pregnancy-Lactation

Interactions

Increased metabolism and subsequent reduction in efficacy with enzyme-inducing agents e.g. carbamazepine, griseofulvin, phenobarbital, phenytoin and rifampicin. Adjustment in antidiabetic dose may be required. Potentially Fatal: May increase plasma levels and toxicity of ciclosporin.

Adverse Effects

Side effects of Lynestrenol : GI disturbances, changes in appetite or weight, fluid retention, oedema, rashes, urticaria, mental depression, breast tenderness and pain, gynaecomastia, changes in libido, headache, migraine, altered menstrual cycle, irregular menstrual bleeding, changes in LFTs and serum lipid profile. Potentially Fatal: Anaphylaxis or anaphylactoid reactions.

Mechanism of Action

Lynestrenol is a progestogen structurally related to norethisterone. It may be used alone or as the progestogenic component of some oral contraceptives.