Magaldrate
Indications
Magaldrate is used for:
Peptic ulcers, GERD, Heartburn, Gastritis
Adult Dose
Heartburn, Sour Stomach, & Acid Indigestion
5-10 mL (1-2 teaspoonfuls; 540-1080 mg) between meals and at bed time.
not to exceed 80 mL (16 teaspoonfuls) in 24-hour period
PO: 1-3 tablets between meals and at bed time.
Child Dose
Safety & efficacy not established
Renal Dose
Administration
Take between meals & at bedtime.
Contra Indications
Magaldrate is contraindicated in patients with known hypersensitivity to magnesium and aluminium. It is also contraindicated in patients with impaired renal functions.
Precautions
Care should be taken in decreased kidney function, hypophosphataemia and weak people.
Lactation: not known whether excreted in breast milk, use caution
Pregnancy-Lactation
Interactions
Magaldrate may negatively influence drugs like tetracyclines, benzodiazepines, and indomethacin. High doses or prolonged usage may lead to an increment of defecation and a reduction in feces consistence. In some cases it can alter the functionality of the gastrointestinal tract, occasionally provoking constipation or diarrhea.
Adverse Effects
Side effects of Magaldrate :
>10%
Aluminum oxide
Chalky taste, Constipation, Fecal impaction, Stomach cramps
Frequency Not Defined
Aluminum oxide
Nausea, Vomiting, Aluminum intoxication, Hypophosphatemia, Osteomalacia,
Magnesium oxide
Diarrhea, Hypermagnesemia
Mechanism of Action
Magaldrate is a hydroxymagnesium aluminate complex that is rapidly converted in gastric acid to magnesium and aluminium hydroxide, which is poorly absorbed and provides a sustained antacid effect with balanced efects on intestinal motility; increases lower esophageal sphincter tone and inhibits smooth muscle contraction and gastric emptying.